Editorial: Radiation-induced and oxidative DNA damages
نویسندگان
چکیده
منابع مشابه
Editorial: Radiation-induced and oxidative DNA damages
The study of DNA lesions and changes, produced by interaction with UV or ionizing radiation and by the effects of oxidative stress, is a multidisciplinary research field in life sciences that has yelded exciting discoveries in the last few decades. The importance of this study is clearly enhanced by its strong societal impact, because of the connections of DNA lesions with carcinogenetic proces...
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UVA (320-400 nm) represents the main spectral component of solar UV radiation, induces pre-mutagenic DNA lesions and is classified as Class I carcinogen. Recently, discussion arose whether UVA induces DNA double-strand breaks (dsbs). Only few reports link the induction of dsbs to UVA exposure and the underlying mechanisms are poorly understood. Using the Comet-assay and γH2AX as markers for dsb...
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BACKGROUND Sonchus arvesis is traditionally reported in various human ailments including hepatotoxicity in Pakistan. Presently we designed to assess the protective effects of methanolic extract of Sonchus arvesis against carbon tetrachloride induced genotoxicity and DNA oxidative damages in hepatic tissues of experimental rats. METHODS 36 male Sprague-Dawley rats were randomly divided into 6 ...
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diseases. These include cancer, Parkinson’s disease, Alzheimer’s disease, atherosclerosis, heart failure, myocardial infarction, Schizophrenia, bipolar disorder, fragile X syndrome, sickle cell disease and chronic fatigue syndrome. Oxidative stress is likely to be involved in agerelated development of cancer. The reactive species produced in oxidative stress can cause direct damage to the DNA a...
متن کاملSpectrum of complex DNA damages depends on the incident radiation.
Ionizing radiation induces bistranded clustered damages--two or more abasic sites, oxidized bases and strand breaks on opposite DNA strands within a few helical turns. Since clusters are refractory to repair and are potential sources of double-strand breaks (DSBs), they are potentially lethal and mutagenic. Although induction of single-strand breaks (SSBs) and isolated lesions has been studied ...
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ژورنال
عنوان ژورنال: Frontiers in Chemistry
سال: 2015
ISSN: 2296-2646
DOI: 10.3389/fchem.2015.00054